(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine

Base Information

• Chemical Name: (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine
• CAS No.: 889886-09-3
• Molecular Formula: C₆₄H₆₁N₅O₂Si
• Molecular Weight: 960.306

Synonyms:(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine

Chemical Property of (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine

There total 6 articles about (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-hydroxy)propyl]adenine (889886-08-2) + trityl chloride (76-83-5) → (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N6-trityladenine (889886-09-3)

Guidance literature:

With pyridine; dmap; triethylamine; for 17h; Heating;

DOI:10.1080/15257770500265612

Reference yield:

(+/-)-5-O-pivaloylpentane-1,3,5-triol (889886-05-9) → (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N6-trityladenine (889886-09-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

2: 70 percent / Ph₃P; diethyl azodicarboxylate / dioxane / 19 h / 20 °C

3: 65 percent / NaOMe / methanol / 17 h / 20 °C

4: 54 percent / DMAP; pyridine; Et₃N / 17 h / Heating

With pyridine; 1H-imidazole; dmap; sodium methylate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1080/15257770500265612

Reference yield:

(+/-)-1-O-pivaloyl-3,5-O-isopropylidenepentane-1,3,5-triol (889886-04-8) → (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N6-trityladenine (889886-09-3)

Guidance literature:

Multi-step reaction with 5 steps

1: AcOH / H₂O / 15 h / 50 - 55 °C

2: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3: 70 percent / Ph₃P; diethyl azodicarboxylate / dioxane / 19 h / 20 °C

4: 65 percent / NaOMe / methanol / 17 h / 20 °C

5: 54 percent / DMAP; pyridine; Et₃N / 17 h / Heating

With pyridine; 1H-imidazole; dmap; sodium methylate; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; dichloromethane; water; 3: Mitsunobu reaction;

DOI:10.1080/15257770500265612

upstream raw materials:

(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-hydroxy)propyl]adenine

trityl chloride

(+/-)-5-O-pivaloylpentane-1,3,5-triol

(+/-)-1-O-pivaloyl-3,5-O-isopropylidenepentane-1,3,5-triol

Downstream raw materials:

(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

(+/-)-9-[(1-trityloxyethyl)(3-di-tert-butylcarbonyloxymethylphosphonomethoxy)propyl]-N⁶-trityladenine

(+/-)-9-[(1-trityloxyethyl)(3-hydroxy)propyl]-N⁶-trityladenine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 889886-09-3 (+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-trityloxy)propyl]-N⁶-trityladenine

Send

Send

Metric Ton KG G Pound L ML

Send

Send