2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester

Base Information

• Chemical Name: 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester
• CAS No.: 60336-71-2
• Molecular Formula: C₁₉H₂₇N₃O₆
• Molecular Weight: 393.44
• Mol file: 60336-71-2.mol

Synonyms:2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester

Chemical Property of 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester

There total 3 articles about 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-tert-butyloxycarbonylasparagine (7536-55-2) + L-alanine benzyl ester hydrochloride (5557-81-3,5557-83-5,34404-37-0) → 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester (60336-71-2)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jo801993k

Reference yield: 73.0%

N-(tert-butyloxycarbonyl)-L-asparagine p-nitrophenyl ester (4587-33-1) + L-alanine benzyl ester p-toluenesulfonate (42854-62-6) → 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester (60336-71-2)

Guidance literature:

With benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1007/BF02758662

Reference yield:

→ 2S-(2S-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester (60336-71-2)

Guidance literature:

BOC-Asn-p-NO2-Ph, Ala-Boc;

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-asparagine p-nitrophenyl ester

L-alanine benzyl ester p-toluenesulfonate

N-tert-butyloxycarbonylasparagine

L-alanine benzyl ester hydrochloride

Downstream raw materials:

H-Asn-Ala-OBzl trifluoroacetic acid salt