(1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane

Base Information

• Chemical Name: (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane
• CAS No.: 1161834-76-9
• Molecular Formula: C₁₉H₁₉N₃O₅S
• Molecular Weight: 401.443
• Mol file: 1161834-76-9.mol

Synonyms:(1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane

Chemical Property of (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane

Chemical Property:

Purity/Quality:

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Technology Process of (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane

There total 6 articles about (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-azabicyclo[4.1.0]heptan-7-yl(3,5-dinitrophenyl)methanone + phenylthiotrimethylsilane (4551-15-9) → (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane (1161834-76-9)

Guidance literature:

With (R)-2,2'-diphenyl-3,3'-biphenanthryl-4,4'-diyl phosphate; In 1,1,1-trichloroethane; at 0 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol901209n

Reference yield: 94.0%

7-(3,5-dinitrobenzoyl)-7-azabicyclo[4.1.0]heptane (884588-09-4) + phenylthiotrimethylsilane (4551-15-9) → (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane (1161834-76-9)

Guidance literature:

With (R)-VAPOL calcium phosphate; magnesium(II) (R)-2,2'-diphenyl-3,3'-biphenanthryl-4,4'-diyl phosphate; In 1,1,1-trichloroethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2012.10.068

Reference yield: 93.0%

7-(3,5-dinitrobenzoyl)-7-azabicyclo[4.1.0]heptane (884588-09-4) + thiophenol (108-98-5) → (1R,2R)-1-phenylthio-2-[N-(3,5-dinitrobenzoyl)amino]cyclohexane (1161834-76-9)

Guidance literature:

With (S)-(+)-2,2'-diphenyl-4-biphenanthrol hydrogen phosphate; In diethyl ether; at 20 ℃; for 20h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol902123h

upstream raw materials:

7-(3,5-dinitrobenzoyl)-7-azabicyclo[4.1.0]heptane

thiophenol

phenylthiotrimethylsilane