1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

Base Information

Chemical Name:1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one
CAS No.:119722-75-7
Molecular Formula:C₅₁H₄₉N₃O₈
Molecular Weight:831.965
Hs Code.:

1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

Synonyms:1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

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Chemical Property of 1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

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Technology Process of 1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

There total 8 articles about 1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 140679-69-2
2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester

: 119722-75-7
1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

Guidance literature:: With potassium hydroxide; sodium tetrahydroborate; In methanol; benzene; for 25h; Ambient temperature;
DOI:10.1039/P19920000469

Reference yield: 71.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 114827-16-6
N⁴-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-threo-pentofuranosyl)-cytosine

: 119722-75-7
1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1246/cl.1987.2419

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 119722-75-7
1-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / pyridine / 3 h / Ambient temperature

2: 56 percent / Mg(OMe)2, NaBH₄ / benzene; methanol / 1.5 h / 65 °C

3: 71 percent / pyridine / Ambient temperature

With pyridine; sodium tetrahydroborate; magnesium methanolate; In methanol; benzene;
DOI:10.1246/cl.1987.2419