N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester

Base Information

• Chemical Name: N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester
• CAS No.: 64569-36-4
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 64569-36-4.mol

Synonyms:N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester

Chemical Property of N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester

There total 1 articles about N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

L-norleucine methyl ester (21754-55-2) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester (64569-36-4)

Guidance literature:

With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2006.05.010

Reference yield: 88.0%

N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester (64569-36-4) → L-phenylalaninyl-L-norleucine methyl ester hydrochloride

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.tet.2006.05.010

Reference yield:

N-tret-butoxycarbonyl-L-phenylalaninyl-L-norleucine methyl ester (64569-36-4) → (3S,6S)-3-Benzyl-6-butyl-piperazine-2,5-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / HCl / methanol / 6 h / 20 °C

2: 97 percent / water; triethylamine / 0.17 h / 140 °C / microwave irradiation

With hydrogenchloride; water; triethylamine; In methanol;

DOI:10.1016/j.tet.2006.05.010

upstream raw materials:

L-norleucine methyl ester

N-tert-butoxycarbonyl-L-phenylalanine