4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester
CAS No.:642070-21-1
Molecular Formula:C₂₇H₂₉NO₆
Molecular Weight:463.53
Hs Code.:

4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid <i>tert</i>-butyl ester

Synonyms:4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

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Chemical Property of 4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

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Technology Process of 4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

There total 4 articles about 4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 642070-20-0
4-[4-(3'-nitro-biphenyl-4-yloxy)-3-oxo-butyl]-benzoic acid tert-butyl ester

: 642070-21-1
4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2003.08.033

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 642070-21-1
4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / Pd(OAc)2; NaHCO₃; (n-Bu)4NBr / toluene / Heating

2: 45 percent / N-ethyl benzothiazolium bromide / ethanol / Heating

3: 88 percent / NEt₃ / CH₂Cl₂ / 20 °C

4: 57 percent / Cs₂CO₃ / acetonitrile / Heating

5: 79 percent / NaBH₄ / ethanol / 20 °C

With palladium diacetate; sodium tetrahydroborate; tetrabutylammomium bromide; sodium hydrogencarbonate; caesium carbonate; triethylamine; 3-ethylbenzothiazolium bromide; In ethanol; dichloromethane; toluene; acetonitrile; 1: Heck reaction;
DOI:10.1016/j.bmcl.2003.08.033

Reference yield:

: 134372-99-9
3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal

: 642070-21-1
4-[3-hydroxy-4-(3'-nitro-biphenyl-4-yloxy)-butyl]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / N-ethyl benzothiazolium bromide / ethanol / Heating

2: 88 percent / NEt₃ / CH₂Cl₂ / 20 °C

3: 57 percent / Cs₂CO₃ / acetonitrile / Heating

4: 79 percent / NaBH₄ / ethanol / 20 °C

With sodium tetrahydroborate; caesium carbonate; triethylamine; 3-ethylbenzothiazolium bromide; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2003.08.033