4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

Base Information

Chemical Name:4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt
CAS No.:1321928-69-1
Molecular Formula:C₇H₅FO₂*C₈H₁₁N₃O₃S
Molecular Weight:369.374
Hs Code.:

Synonyms:4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

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Chemical Property of 4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

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Technology Process of 4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

There total 2 articles about 4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147027-10-9,147126-73-6,147126-74-7,147126-80-5
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

: 445-29-4
o-fluoro-benzoic acid

: 1321928-69-1
4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

Guidance literature:: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; With sodium tetrahydroborate; dipotassium hydrogenphosphate; sodium hydroxide; In industrially methylated spirit; water; at 18 - 22 ℃; for 4h;

o-fluoro-benzoic acid; In water; at 22 - 42 ℃;

Reference yield:

: 147126-78-1
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[4-(methylcarboxamido)-2-oxo-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate

: 1321928-69-1
4-amino-1-((2R,5S)-2-hydroxymethyl-[1,3]oxothiolane-5-yl)-1H-pyrimidin-3-one 2-fluorobenzoic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonic acid / methanol / 4 h

1.2: 0.17 h

2.1: sodium hydroxide; dipotassium hydrogenphosphate; sodium tetrahydroborate / water; industrially methylated spirit / 4 h / 18 - 22 °C

2.2: 22 - 42 °C

With sodium tetrahydroborate; dipotassium hydrogenphosphate; methanesulfonic acid; sodium hydroxide; In methanol; industrially methylated spirit; water;