6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE

Base Information

• Chemical Name: 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE
• CAS No.: 960535-41-5
• Molecular Formula: C₇H₂BrClFNS
• Molecular Weight: 266.521
• Mol file: 960535-41-5.mol

Synonyms:6-bromo-2-chloro-4-fluoro-1,3-benzothiazole

Chemical Property of 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE

There total 4 articles about 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

potassium ethyl xanthogenate (140-89-6) + 4-bromo-2,6-difluoroaniline (67567-26-4) → 6-bromo-2-chloro-4-fluoro-1,3-benzothiazole (960535-41-5)

Guidance literature:

potassium ethyl xanthogenate; 4-bromo-2,6-difluoroaniline; In N,N-dimethyl-formamide; at 130 ℃;

With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 48h;

Reference yield: 56.1%

6-bromo-4-fluorobenzo[d]thiazol-2-amine (383131-45-1) → 6-bromo-2-chloro-4-fluoro-1,3-benzothiazole (960535-41-5)

Guidance literature:

With copper dichloride; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; at 20 - 60 ℃; for 1.16667h; Inert atmosphere;

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) → 6-bromo-2-chloro-4-fluoro-1,3-benzothiazole (960535-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / acetic acid / 2.25 h / 20 °C

1.2: Cooling in ice

2.1: copper dichloride; isopentyl nitrite / 1-methyl-pyrrolidin-2-one / 1.17 h / 20 - 60 °C / Inert atmosphere

With bromine; copper dichloride; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; acetic acid;

upstream raw materials:

4-bromo-2-fluoroaniline

6-bromo-4-fluorobenzo[d]thiazol-2-amine

potassium ethyl xanthogenate

4-bromo-2,6-difluoroaniline