ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate

Base Information

• Chemical Name: ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate
• CAS No.: 1334953-79-5
• Molecular Formula: C₁₇H₁₉N₃O₅
• Molecular Weight: 345.355

Synonyms:ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate

Chemical Property of ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate

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Technology Process of ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate

There total 2 articles about ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-acetylaminoantipyrine (83-15-8) + oxalic acid diethyl ester (95-92-1) → ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate (1334953-79-5)

Guidance literature:

4-acetylaminoantipyrine; oxalic acid diethyl ester; With sodium ethanolate; for 5h; Reflux;

With acetic acid;

DOI:10.1016/j.ejmech.2011.07.035

Reference yield:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) → ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate (1334953-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / Reflux

2: sodium ethanolate / 5 h / Reflux

With sodium ethanolate;

DOI:10.1016/j.ejmech.2011.07.035

Reference yield: 83.0%

ethyl 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2,4-dioxobutanoate (1334953-79-5) → N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-hydrazinyl-3,4-dioxobutanamide (1334953-89-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2011.07.035

upstream raw materials:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

4-acetylaminoantipyrine

oxalic acid diethyl ester

Downstream raw materials:

N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-hydrazinyl-3,4-dioxobutanamide

N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-3-(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propanamide

C₂₁H₂₀N₆O₄

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