(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

Base Information

Chemical Name:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid
CAS No.:145337-57-1
Molecular Formula:C₁₅H₂₈N₂O₄
Molecular Weight:300.398
Hs Code.:

Synonyms:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

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Chemical Property of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

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Technology Process of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

There total 1 articles about (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 145337-57-1
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NEt₃ / ethyl acetate / Heating

2: pyridine

3: NaH

4: H₂ / Pd-C

5: N-methylmorpholine / toluene / Heating

6: EDAC, HOBT

7: CF₃SO₂OSiMe₃, NEt₃ / dioxane / Heating

With 4-methyl-morpholine; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; pyridine; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(97)00416-2

Reference yield: 82.0%

: 145337-57-1
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

: 145337-55-9
(2R)-N₁-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N₄-hydroxy-2-(2-methylpropyl)-butanediamide

Guidance literature:: With dmap; 4-(aminoxymethyl)-2-methoxyphenoxymethyl-copoly(styrene-1..; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 18h;

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid; With trifluoroacetic acid; In dichloromethane; for 0.25h;
DOI:10.1016/S0040-4020(99)00347-6

Reference yield: 54.0%

: 145337-57-1
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

: 215607-30-0
O-(2,4-dimethoxybenzyl)-N-(2,4,6-trimethoxybenzyl)hydroxylamine

: N⁴-(2,4-dimethoxy-benzyloxy)-N¹-(2,2-dimethyl-1-methylcarbamoyl-propyl)-2-isobutyl-N⁴-(2,4,6-trimethoxy-benzyl)-succinamide

Guidance literature:: With 1-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01760-2