4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

Base Information

Chemical Name:4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone
CAS No.:770251-13-3
Molecular Formula:C₃₀H₃₂N₃O₁₂P
Molecular Weight:657.571
Hs Code.:

Synonyms:4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

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Chemical Property of 4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

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Technology Process of 4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

There total 12 articles about 4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 770251-05-3
(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetic acid

: C₂₅H₃₆NO₇P

: 770251-13-3
4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

Guidance literature:: (1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetic acid; C₂₅H₃₆NO₇P; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 18h;

With trifluoroacetic acid; for 1h;

Reference yield:

: 19499-82-2
5-(N,N-dimethylaminomethyl)indol-4-ol

: 770251-13-3
4-{2-[(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetamido]ethoxy}-4'-[2-(dihydroxyphosphoryloxy)ethoxy]benzophenone

Guidance literature:: Multi-step reaction with 9 steps

1.1: 87 percent / H₂ / Pd-alumina / ethanol / 3800 Torr

2.1: NaBH₃CN; AcOH / 1 h / 15 °C

3.1: 73 percent / AcOH / 1 h / Heating

4.1: 80 percent / aq. NaOH / methanol / 0.75 h / 20 °C

5.1: K₂CO₃ / acetone / 0.25 h

5.2: 90 percent / acetone / 4 h / Heating

6.1: 66 percent / claycop; acetic anhydride / CCl₄ / 4 h / 20 °C

7.1: 75 percent / TFA / 1 h / 20 °C

8.1: 85 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / 18 h / 20 °C

9.1: TFA / 1 h / 20 °C

With sodium hydroxide; hydrogen; acetic anhydride; sodium cyanoborohydride; potassium carbonate; copper(II) nitrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium matal-containing silica-supported catalyst; In methanol; tetrachloromethane; ethanol; acetone;
DOI:10.1016/j.tet.2004.10.094