tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

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Chemical Name:tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane
CAS No.:646523-23-1
Molecular Formula:C₂₈H₄₈O₅Si
Molecular Weight:492.772
Hs Code.:

Synonyms:tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

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Chemical Property of tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

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Technology Process of tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

There total 10 articles about tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 646523-19-5
tert-Butyl-(5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-ynyloxy)-dimethyl-silane

: 646523-23-1
tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

Guidance literature:: With hydrogen; Lindlar's catalyst; In methanol; at 25 ℃;
DOI:10.1055/s-2003-42071

Reference yield:

: 119649-27-3
4-((4-methoxybenzyl)oxy)butanal

: 646523-23-1
tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1.1: 95 percent / diethyl ether / 0 - 25 °C

2.1: LDA / tetrahydrofuran / 0 °C

2.2: 86 percent / tetrahydrofuran / -120 - 25 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

4.1: CH₂Cl₂ / 25 °C

5.1: 96 percent / AD-mix β; aq. MeSO2NH2 / 2-methyl-propan-2-ol / 0 °C

6.1: p-toluenesulfonic acid / 25 °C

7.1: 95 percent / LAH / diethyl ether / 0 °C

8.1: 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / -40 - -30 °C

9.1: t-BuLi; DMPU / tetrahydrofuran / -78 °C

9.2: tetrahydrofuran / -78 - 25 °C

10.1: 94 percent / H₂ / Lindlar catalyst / methanol / 25 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; methanesulfonamide; hydrogen; tert.-butyl lithium; toluene-4-sulfonic acid; ozone; 1,4-bis(9-O-dihydroquinidine)phthalazine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol; 4.1: Wittig olefination / 5.1: Sharpless asymmetric dihydroxylation / 10.1: Lindlar reduction;
DOI:10.1055/s-2003-42071

Reference yield:

: 1057719-63-7
4-(4-methoxybenzyloxy)-2-methylbutanal

: 646523-23-1
tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: CH₂Cl₂ / 25 °C

2.1: 96 percent / AD-mix β; aq. MeSO2NH2 / 2-methyl-propan-2-ol / 0 °C

3.1: p-toluenesulfonic acid / 25 °C

4.1: 95 percent / LAH / diethyl ether / 0 °C

5.1: 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / -40 - -30 °C

6.1: t-BuLi; DMPU / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran / -78 - 25 °C

7.1: 94 percent / H₂ / Lindlar catalyst / methanol / 25 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; methanesulfonamide; hydrogen; tert.-butyl lithium; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol; 1.1: Wittig olefination / 2.1: Sharpless asymmetric dihydroxylation / 7.1: Lindlar reduction;
DOI:10.1055/s-2003-42071