5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

Base Information

Chemical Name:5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone
CAS No.:1310584-45-2
Molecular Formula:C₂₂H₁₃F₂N₃O
Molecular Weight:373.362
Hs Code.:

Synonyms:5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

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Chemical Property of 5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

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Technology Process of 5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

There total 5 articles about 5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 610278-16-5
3-(4-(fluoro)phenyl)imidazo[1,5-a]pyridine-1-carbaldehyde

: 1310584-45-2
5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

Guidance literature:: With piperidine; In methanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2011.03.027

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 1310584-45-2
5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2: trichlorophosphate / 3 h / Reflux

3: trichlorophosphate / 2 h / Heating

4: piperidine / methanol / 3 h / Reflux

With piperidine; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2011.03.027

Reference yield:

: 3-(4-fluorophenyl)imidazo[1,5-a]pyridine

: 1310584-45-2
5-fluoro-3-(E)-1-[3-(4-fluorophenyl)imidazo[1,5-a]pyridin-1-yl]methylidene-2-indolinone

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / Heating

2: piperidine / methanol / 3 h / Reflux

With piperidine; trichlorophosphate; In methanol;
DOI:10.1016/j.ejmech.2011.03.027