2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Base Information

Chemical Name:2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid
CAS No.:1343454-42-1
Molecular Formula:C₂₃H₂₉N₃O₅S
Molecular Weight:459.566
Hs Code.:

Synonyms:2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

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Chemical Property of 2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

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Technology Process of 2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

There total 10 articles about 2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 2-[3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid ethyl ester

: 1343454-42-1
2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: 2-[3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield: 8.0%

: 1343454-44-3
2-[3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid methyl ester

: 1343454-42-1
2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: 2-[3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1343454-42-1
2-[3-(6-methanesulfonyl-aminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux

2.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C

3.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 60 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 25 °C

5.2: 1 h / 25 °C

6.1: hydrogenchloride; iron / ethanol; water / 1 h / 95 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 96 h / 25 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 5 h / 50 °C

With hydrogenchloride; triethylsilane; water; iron; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide; ytterbium(III) trifluoromethanesulfonate hydrate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: Diels-Alder Reaction;