whi-p131hydrochloride dihydrate

Base Information

• Chemical Name: whi-p131hydrochloride dihydrate
• CAS No.: 188829-39-2
• Molecular Formula: C₁₆H₁₅N₃O₃*ClH
• Molecular Weight: 333.774
• Mol file: 188829-39-2.mol

Synonyms:Phenol,4-[(6,7-dimethoxy-4-quinazolinyl)amino]-, monohydrochloride (9CI); 4-[4-Hydroxyphenylamino]-6,7-dimethoxyquinazolinehydrochloride

Chemical Property of whi-p131hydrochloride dihydrate

Chemical Property:

• PSA: 76.50000
• LogP: 3.97120
• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

Technology Process of whi-p131hydrochloride dihydrate

There total 8 articles about whi-p131hydrochloride dihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline hydrochloride (188829-39-2)

Guidance literature:

Reference yield: 84.0%

4-amino-phenol (123-30-8) + 6,7-dimethoxy-4-chloroquinazoline (13790-39-1) → 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline hydrochloride (188829-39-2)

Guidance literature:

In isopropyl alcohol; for 3h; Reflux;

Reference yield:

3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline hydrochloride (188829-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: POCl₃

2.1: ethanol / 0.25 h / Heating

2.2: HCl

With trichlorophosphate; In ethanol; 1.1: Substitution / 2.1: Substitution / 2.2: Addition;

DOI:10.1016/S0960-894X(97)00034-6

upstream raw materials:

4-amino-phenol

6,7-dimethoxy-4-chloroquinazoline

2-Amino-4,5-dimethoxybenzoic acid

3H-6,7-dimethoxyquinazolin-4-one

Refernces

• 1、 Yang, Su Hui,Khadka, Daulat Bikram,Cho, Suk Hee,Ju, Hye-Kyung,Lee, Kwang Youl,Han, Ho Jae,Lee, Kyung-Tae,Cho, Won-Jea. "Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors". experimental part. p. 968 - 977. Retrieved 2011/03/17.
• 2、 Myers, Michael R.,Setzer, Natalie N.,Spada, Alfred P.,Zulli, Allison L.,Hsu, Chin-Yi J.,Zilberstein, Asher,Johnson, Susan E.,Hook, Linda E.,Jacoski, Mary V.. "The preparation and SAR of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56(lck) and EGF-R tyorsine kinase activity". . p. 417 - 420. Retrieved 2007/10/03.