7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Base Information

Chemical Name:7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid
CAS No.:1394135-90-0
Molecular Formula:C₂₈H₁₇F₃N₄O₃S
Molecular Weight:546.529
Hs Code.:

Synonyms:7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Chemical Property of 7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Technology Process of 7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

There total 2 articles about 7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₂₉F₃N₄O₃SSi

: 1394135-90-0
7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2012.06.018

Reference yield:

: 1345974-42-6
2-(trimethylsilyl)ethyl 2-ethynyl-7-(naphthalen-1-ylmethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]-pyridine-3-carboxylate

: 1394135-90-0
7-(naphthalen-1-ylmethyl)-5-oxo-2-(1H-1,2,3-triazol-4-yl)-8-(3-(trifluoromethyl)phenyl)-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) thiophene-2-carboxylate; sodium azide / water; dimethyl sulfoxide / 18 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With sodium azide; copper(I) thiophene-2-carboxylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.06.018