tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

Base Information

Chemical Name:tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate
CAS No.:781650-40-6
Molecular Formula:C₂₀H₂₈F₂N₂O₄
Molecular Weight:398.45
Hs Code.:

Synonyms:tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

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Chemical Property of tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

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Technology Process of tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

There total 3 articles about tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6482-24-2
2-Bromoethyl methyl ether

: 781650-40-6
tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

Guidance literature:: tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.0833333h;

2-Bromoethyl methyl ether; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 3h;

With water; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 781650-32-6
tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 781650-40-6
tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

Guidance literature:: tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

: 781650-32-6
tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate

: 781650-40-6
tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl))carbamate

Guidance literature:: tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

CH₃OCH₂CH₂X; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm070668p