{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

Base Information

Chemical Name:{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane
CAS No.:267668-83-7
Molecular Formula:C₁₇H₂₄O₄Si
Molecular Weight:320.461
Hs Code.:

Synonyms:{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

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Chemical Property of {3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

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Technology Process of {3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

There total 2 articles about {3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 38002-45-8
3-bromo-1-(trimethylsilyl)-1-propyne

: 103477-58-3
2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

: 267668-83-7
{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

Guidance literature:: 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane; With magnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

3-bromo-1-(trimethylsilyl)-1-propyne; In tetrahydrofuran; diethyl ether; for 2h; Further stages.; Heating;
DOI:10.1002/1099-0690(200109)2001:17<3313::AID-EJOC3313>3.0.CO;2-E

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 267668-83-7
{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: PTSA

2.1: n-BuLi

2.2: MgBr₂

With n-butyllithium; toluene-4-sulfonic acid; 1.1: Condensation / 2.1: Substitution / 2.2: Grignard reaction / 2.3: Substitution;
DOI:10.1021/ol0056832

Reference yield: 84.0%

: 267668-83-7
{3-[2'-(1,3-dioxolan-2-yl)-4',5'-dimethoxyphenyl]prop-1-ynyl}-trimethylsilane

: 267668-95-1
4,5-dimethoxy-2-[3'-(trimethylsilyl)prop-2'-ynyl]benzaldehyde

Guidance literature:: With water; toluene-4-sulfonic acid; In acetone; for 2h; Heating;
DOI:10.1002/1099-0690(200109)2001:17<3313::AID-EJOC3313>3.0.CO;2-E