tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

Base Information

Chemical Name:tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate
CAS No.:211103-57-0
Molecular Formula:C₃₄H₃₉N₅O₇
Molecular Weight:629.713
Hs Code.:

Synonyms:tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

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Chemical Property of tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

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Technology Process of tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

There total 1 articles about tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 766491-96-7
[1-(4-nitrobenzyl)imidazol-2-yl]acetic acid

: 159183-36-5
tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate

: 211103-57-0
tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 14h;
DOI:10.1016/j.bmc.2009.03.044

Reference yield: 94.0%

: 211103-57-0
tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

: (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(1H-imidazol-2-yl)acetanilide dihydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2009.03.044

Reference yield: 56.0%

: 211103-57-0
tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate

: 211103-59-2
tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-{[2-(1H-imidazol-2-yl)acetyl]-amino}phenyl)ethyl]carbamate

Guidance literature:: tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-{2-[4-({2-[1-(4-nitrobenzyl)imidazol-2-yl]acetyl}amino)phenyl]ethyl}carbamate; With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 0.0833333h;

With 10% palladium on charcoal; hydrogen; In methanol; for 5h;

With sodium hydroxide; In methanol; chloroform; water;
DOI:10.1016/j.bmc.2009.03.044