(3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester

Base Information

• Chemical Name: (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester
• CAS No.: 116761-31-0
• Molecular Formula: C₂₇H₄₀O₉
• Molecular Weight: 508.609
• Mol file: 116761-31-0.mol

Synonyms:(3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester

Chemical Property of (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester

There total 14 articles about (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3R)-3-<<(3'R)-3'-hydroxybutanoyl>oxy>butanoic acid tert-butyl ester (116761-28-5) + (3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoyl chloride → (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester (116761-31-0)

Guidance literature:

With pyridine; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1002/hlca.19930760518

Reference yield:

(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester (116761-27-4) → (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester (116761-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂ / Pd/C / ethanol; acetic acid / 5 h / Ambient temperature

2: pyridine / CH₂Cl₂ / -78 °C / to RT

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2430::AID-HLCA2430>3.0.CO;2-W

Reference yield:

tert-butyl (R)-3-hydroxybutanoate (110171-06-7) → (3R)-3-<<(3'R)-3'-<<(3R)-3-<<(3'R)-3'-(benzyloxy)butyryl>oxy>butyryl>oxy>butyryl>oxy>butyric acid-(tert-butyl)ester (116761-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / -78 °C / to RT

2: 93 percent / H₂ / Pd/C / ethanol; acetic acid / 5 h / Ambient temperature

3: pyridine / CH₂Cl₂ / -78 °C / to RT

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2430::AID-HLCA2430>3.0.CO;2-W

upstream raw materials:

(3R)-3-<<(3'R)-3'-hydroxybutanoyl>oxy>butanoic acid tert-butyl ester

O-benzyl 2,2,2-trichloroacetimidate

tert-butyl (R)-3-hydroxybutanoate

(R)-3-(benzyloxy)butanoyl chloride

Downstream raw materials:

(R,R,R,R,R,R,R,R)-α-benzyl-ω-(tert-butoxy)octakis

(R,R,R,R,R,R,R,R)-α-benzyl-ω-hydroxyoctakis

(R,R,R,R,R)-α-benzyl-ω-(tert-butoxy)pentakis

(R,R,R,R,R,R)-α-benzyl-ω-(tert-butoxy)hexakis