(1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

Base Information

• Chemical Name: (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol
• CAS No.: 226989-87-3
• Molecular Formula: C₂₄H₃₆O₇Si
• Molecular Weight: 464.631
• Mol file: 226989-87-3.mol

Synonyms:(1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

Chemical Property of (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

There total 1 articles about (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-1-(3',4',5'-Trimethoxyphenyl)-2-(4''-methoxy-3''-tert-butyldimethylsiloxyphenyl)ethene (121042-96-4) → (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol (226989-87-3)

Guidance literature:

With methanesulfonamide; In water; butan-1-ol; for 72h; AD mix-α;

DOI:10.1021/jm9807149

Reference yield: 93.0%

4-chlorobenzoyl chloride (586-75-4) + (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol (226989-87-3) → (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane (226990-01-8)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; a) RT, 4 h, b) from 45 deg C to 85 deg C, 16 h;

DOI:10.1021/jm9807149

Reference yield: 81.0%

acetic anhydride (108-24-7) + (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol (226989-87-3) → (1S,2S)-1,2-diacetoxy-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 0.833333h;

DOI:10.1021/jm9807149

upstream raw materials:

(E)-1-(3',4',5'-Trimethoxyphenyl)-2-(4''-methoxy-3''-tert-butyldimethylsiloxyphenyl)ethene

Downstream raw materials:

(1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

(1S,2S)-1-(3-Hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol