4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester
CAS No.:507480-28-6
Molecular Formula:C₂₆H₂₉NO₆
Molecular Weight:451.519
Hs Code.:

Synonyms:4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

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Chemical Property of 4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

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Technology Process of 4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

There total 7 articles about 4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 507480-08-2
(4R,6R,7S)-6-(4-Methoxy-benzyloxy)-7-methyl-dec-1-en-9-yn-4-ol

: 62-23-7
4-nitro-benzoic acid

: 507480-28-6
4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; at 20 ℃; for 6h;
DOI:10.1021/jo026798h

Reference yield:

: 507480-04-8
(2R,4R)-2-(4-methoxyphenyl)-4-((S)-1-methyl-prop-2-enyl)-[1,3]dioxane

: 507480-28-6
4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ozone / CH₂Cl₂; methanol / -78 °C

1.2: 83 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 20 °C

2.1: 77 percent / pyridine; DMAP / CH₂Cl₂ / 15 h / 20 °C

3.1: 71 percent / dimethylsulfoxide / 15 h / 20 °C

4.1: 92 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / -78 - -40 °C

5.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 1 h / 20 °C

6.1: 413 mg / diethyl ether / 0.33 h / 0 °C

7.1: 71 percent / diethyl azodicarboxylate; triphenylphosphine / benzene / 6 h / 20 °C

With pyridine; dmap; diisobutylaluminium hydride; Dess-Martin periodane; ozone; triphenylphosphine; diethylazodicarboxylate; In methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; benzene; 5.1: Dess-Martin oxidation / 7.1: Mitsunobu reaction;
DOI:10.1021/jo026798h

Reference yield:

: 507480-25-3
(3R,4S)-3-(4-Methoxy-benzyloxy)-4-methyl-hept-6-ynal

: 507480-28-6
4-Nitro-benzoic acid (1S,3R,4S)-1-allyl-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 413 mg / diethyl ether / 0.33 h / 0 °C

2: 71 percent / diethyl azodicarboxylate; triphenylphosphine / benzene / 6 h / 20 °C

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; benzene; 2: Mitsunobu reaction;
DOI:10.1021/jo026798h