(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

Base Information

Chemical Name:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine
CAS No.:1269662-74-9
Molecular Formula:C₃₃H₃₃ClN₆O₃
Molecular Weight:597.116
Hs Code.:

Synonyms:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

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Chemical Property of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

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Technology Process of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

There total 3 articles about (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.9%

: 41467-01-0
N-methylpiperidine-2-carboxaldehyde

: 1269662-79-4
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate

: 1269662-74-9
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

Guidance literature:: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; for 0.5h; Cooling with dry ice;

N-methylpiperidine-2-carboxaldehyde; In tetrahydrofuran; toluene; at 20 ℃; for 12.5h; Cooling with dry ice;

Reference yield:

: 20845-34-5
(1-methyl-piperidin-2-yl)-methanol

: 1269662-74-9
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / Cooling with dry ice

1.2: 1.17 h / 20 °C / Cooling with dry ice

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / Cooling with dry ice

2.2: 12.5 h / 20 °C / Cooling with dry ice

With oxalyl dichloride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 848139-78-6
6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile

: 1269662-74-9
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-piperidinyl)prop-2-enoylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 40 °C

1.2: 12 h / 40 °C

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / Cooling with dry ice

2.2: 12.5 h / 20 °C / Cooling with dry ice

With 1,1'-carbonyldiimidazole; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;