1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1211517-43-9
Molecular Formula:C₁₈H₁₀F₃NO₅
Molecular Weight:377.276
Hs Code.:

Synonyms:1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 5 articles about 1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1211517-53-1
ethyl 1-(2-ethoxy-2-oxo-1-phenylethyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 1211517-43-9
1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With sulfuric acid; In water; toluene; for 6h; Reflux;
DOI:10.1007/s00044-010-9509-9

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 1211517-43-9
1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / Reflux

2: toluene / 50 °C

3: toluene / 5 h / 20 °C

4: potassium carbonate / toluene / 8 h / 100 °C

5: sulfuric acid / water; toluene / 6 h / Reflux

With thionyl chloride; sulfuric acid; potassium carbonate; In water; toluene;
DOI:10.1007/s00044-010-9509-9

Reference yield:

: C₂₂H₁₉F₄NO₅

: 1211517-43-9
1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / toluene / 8 h / 100 °C

2: sulfuric acid / water; toluene / 6 h / Reflux

With sulfuric acid; potassium carbonate; In water; toluene;
DOI:10.1007/s00044-010-9509-9