(2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol

Base Information

Chemical Name:(2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol
CAS No.:188744-98-1
Molecular Formula:C₁₁H₁₅NO₄
Molecular Weight:225.244
Hs Code.:
DSSTox Substance ID:DTXSID90940380
Nikkaji Number:J1.570.953G
Wikidata:Q82917017
ChEMBL ID:CHEMBL4783560
Mol file:188744-98-1.mol

Synonyms:188744-98-1;CHEMBL4783560;3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(4-hydroxyphenyl)-, (2R,3R,4S,5S)-;(2S,3S,4S,5S)-2-(HYDROXYMETHYL)-5-(4-HYDROXYPHENYL)PYRROLIDINE-3,4-DIOL;DTXSID90940380;BRPXIQPSCKPBLH-NAKRPEOUSA-N;BDBM50550996;2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol;(2S)-3alpha,4beta-Dihydroxy-5alpha-(4-hydroxyphenyl)pyrrolidine-2beta-methanol

Suppliers and Price of (2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol

Chemical Property:

PSA：0.00000
LogP:0.00000
XLogP3:-0.6
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:225.10010796
Heavy Atom Count:16
Complexity:230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2C(C(C(N2)CO)O)O)O
Isomeric SMILES:C1=CC(=CC=C1[C@H]2[C@@H]([C@H]([C@@H](N2)CO)O)O)O

Technology Process of (2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol

There total 81 articles about (2S,3S,4S,5S)-2-(Hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (2R,3R,4R,5R)-3,4-dihydroxy-2-(hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine hydrochloride

: 188744-98-1,431981-75-8
(2R,3R,4R,5R)-4-(hydroxy)-2-(hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidin-3-ol

Guidance literature:: With ammonium hydroxide;
DOI:10.1055/s-2007-991059

Reference yield: 96.0%

: 1615251-24-5
(2S,3R,4R,5S)-benzyl 3,4-bis(benzyloxy)-2-(4-(benzyloxy)-phenyl)-5-(trityloxymethyl)pyrrolidine-1-carboxylate

: 1615251-28-9,188744-98-1,431981-75-8
(2S,3R,4R,5S)-2-(hydroxymethyl)-5-(4-hydroxyphenyl)-pyrrolidine-3,4-diol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c4ob00503a

Reference yield: 93.0%

: 904893-28-3
(2S,3S,4S,5S)-2-benzyloxymethyl-3,4-dibenzyloxy-5-(4-benzyloxyphenyl)-N-hydroxy-pyrrolidine

: 905286-72-8,188744-98-1,431981-75-8
(2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine

Guidance literature:: With hydrogen; acetyl chloride; palladium on activated charcoal; In methanol; dichloromethane; for 20h; under 760 Torr;
DOI:10.1021/ol0609210