2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

Base Information

Chemical Name:2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol
CAS No.:128684-71-9
Molecular Formula:C₃₇H₅₈O₈SSi
Molecular Weight:691.014
Hs Code.:

2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

Synonyms:2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

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Chemical Property of 2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

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Technology Process of 2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

There total 10 articles about 2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109466-73-1
(-)-(1R,2R,4R)-4-hydroxymethyl-2-methoxycyclohexan-1-ol

: 128684-71-9
2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / I₂, PPh₃, pyridine / benzene / 2 h / Heating

2: dimethylformamide / 0.33 h / 100 °C

3: Et₃N / CH₂Cl₂ / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 2 h

With pyridine; n-butyllithium; iodine; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00170a024

Reference yield:

: 118207-42-4
(1R,2R,4R)-4-(iodomethyl)-2-methoxycyclohexan-1-ol

: 128684-71-9
2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 0.33 h / 100 °C

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 2 h

With n-butyllithium; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00170a024

Reference yield:

: 118207-39-9
(4R,5S)-5-ethenyl-4-methoxytetrahydro-2H-pyran-2-one

: 128684-71-9
2-Benzenesulfonyl-1-[(4S,5R,6S)-6-(2-benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanol

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / 1.) -78 deg C, 90 min, 2.) 0 deg C, 60 min

2: toluene / 76 h / Heating

3: 1 N HCl / toluene; tetrahydrofuran / 3 h / Ambient temperature

4: 1.) a) BH₃, 2.) 30percent H₂O₂, 0.1 N NaOH / tetrahydrofuran / 3 h / Ambient temperature; 1.) a) THF, from -78 deg C to RT, b) RT, 90 min, 2.) THF, RT, 3 h

5: 78 percent / I₂, PPh₃, pyridine / benzene / 2 h / Heating

6: dimethylformamide / 0.33 h / 100 °C

7: Et₃N / CH₂Cl₂ / Ambient temperature

8: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 2 h

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; borane; dihydrogen peroxide; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/ja00170a024