methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

Base Information

Chemical Name:methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate
CAS No.:83289-24-1
Molecular Formula:C₂₇H₃₀N₆O₆
Molecular Weight:534.572
Hs Code.:

Synonyms:methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

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Chemical Property of methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

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Technology Process of methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

There total 8 articles about methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119-26-6
(2,4-dinitro-phenyl)-hydrazine

: 83289-24-1
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Br₂ / 1.) 65 deg C, 2.) glacial acetic acid, 15 min

2: 93.3 percent / Et₃N / ethyl acetate / 16 h

3: 72 percent / 1.) KBH₄ / acetonitrile; acetic acid / 1.) 4 deg C, 2.) room temperature, 16 h

With potassium borohydride; bromine; triethylamine; In acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/jo00145a028

Reference yield:

: 78178-96-8
methyl bromopyruvate 2,4-dinitrophenylhydrazone

: 83289-24-1
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93.3 percent / Et₃N / ethyl acetate / 16 h

2: 72 percent / 1.) KBH₄ / acetonitrile; acetic acid / 1.) 4 deg C, 2.) room temperature, 16 h

With potassium borohydride; triethylamine; In acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/jo00145a028

Reference yield:

: 83220-17-1,83220-18-2
(12aS,12bS)-11-[(2,4-Dinitro-phenyl)-hydrazono]-12a-ethyl-2,3,4,5,11,12,12a,12b-octahydro-1H-3a,9b-diaza-benzo[a]naphtho[2,1,8-cd]azulen-10-one

: 83289-24-1
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.12 g / NaOCH₃ / CH₂Cl₂ / 96 h / Ambient temperature

2: acetonitrile; aq. HCl / 16 h / Ambient temperature

With sodium methylate; In hydrogenchloride; dichloromethane; acetonitrile;
DOI:10.1021/jo00145a028