3-(S)--tetrahydrofuran-2,5-dione

Base Information

Chemical Name:3-(S)--tetrahydrofuran-2,5-dione
CAS No.:172267-48-0
Molecular Formula:C₁₄H₁₇NO₆S
Molecular Weight:327.358
Hs Code.:

3-(S)-<N-(4-methoxy-2,3,5-trimethylphenylsulfonyl)-amino>-tetrahydrofuran-2,5-dione

Synonyms:3-(S)--tetrahydrofuran-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(S)--tetrahydrofuran-2,5-dione

Chemical Property:

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Technology Process of 3-(S)--tetrahydrofuran-2,5-dione

There total 2 articles about 3-(S)--tetrahydrofuran-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 172267-50-4
N-(4-methoxy-2,3,5-trimethylphenylsulfonyl)-L-aspartic acid

: 172267-48-0
3-(S)--tetrahydrofuran-2,5-dione

Guidance literature:: With thionyl chloride; In ethyl acetate; 1.) 0 deg C to 20 deg C, 1.5 h; 2.) 20 deg C, 45 min;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 80745-07-9
4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

: 172267-48-0
3-(S)--tetrahydrofuran-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / iPr₂NH / dimethylformamide; H₂O / 4 h / 0 °C

2: 87 percent / thionyl chloride / ethyl acetate / 1.) 0 deg C to 20 deg C, 1.5 h; 2.) 20 deg C, 45 min

With thionyl chloride; diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 172267-48-0
3-(S)--tetrahydrofuran-2,5-dione

: CRC 220

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 4 h / 20 °C

2: 76 percent / MEPA / ethyl acetate / 16 h / 25 °C

3: 51 percent / hydroxylamine hydrochloride, NEt₃ / ethanol / 5 h / Heating

4: 93 percent / H₂ / 10percent Pd/C / acetic acid / 18 h / 50 °C / 7500.6 Torr

With hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00765-Z