Technology Process of C17H13F3O3
There total 4 articles about C17H13F3O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C14H9F3O2;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
monomethyl monopotassium malonate;
With
magnesium chloride;
In
tetrahydrofuran;
at 60 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=6 - 7;
DOI:10.1016/j.bmc.2011.07.037
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chloro-trimethyl-silane; ethylene dibromide; zinc / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere
1.2: 60 °C / Inert atmosphere; Reflux
2.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 50 °C
2.2: pH 2 / Cooling with ice
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C
3.2: 60 °C
3.3: pH 6 - 7
With
chloro-trimethyl-silane; ethylene dibromide; 1,1'-carbonyldiimidazole; lithium hydroxide; zinc;
In
tetrahydrofuran; water;
DOI:10.1016/j.bmc.2011.07.037
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 50 °C
1.2: pH 2 / Cooling with ice
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C
2.2: 60 °C
2.3: pH 6 - 7
With
1,1'-carbonyldiimidazole; lithium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1016/j.bmc.2011.07.037
