(R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate

Base Information

• Chemical Name: (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate
• CAS No.: 143329-95-7
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 143329-95-7.mol

Synonyms:(R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate

Chemical Property of (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate

There total 4 articles about (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.9%

α,α',α''-trimethyl-1,3,5-benzenetrimethanol triacetate (111443-89-1,143394-18-7,148496-74-6) → (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate (143329-95-7) + (R,S,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol diacetate (143329-94-6) + (R,R,R)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol (37394-26-6,143394-14-3,143394-15-4,143394-16-5,143394-17-6,147977-11-5,147977-12-6)

Guidance literature:

In benzene; for 672h; 0.1M potassium phosphate buffer, Amano P lipoprotein lipase;

DOI:10.1021/jo00045a042

Reference yield:

1,3,5-triacetylbenzene (779-90-8) → (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate (143329-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium borohydride / propan-2-ol

2: 92 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 2 h

3: 32 percent / benzene / 672 h / 0.1M potassium phosphate buffer, Amano P lipoprotein lipase

With dmap; sodium tetrahydroborate; triethylamine; In dichloromethane; isopropyl alcohol; benzene;

DOI:10.1021/jo00045a042

Reference yield:

α,α',α''-trimethyl-1,3,5-benzenetrimethanol (37394-26-6,143394-14-3,143394-15-4,143394-16-5,143394-17-6,147977-11-5,147977-12-6) → (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate (143329-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 2 h

2: 32 percent / benzene / 672 h / 0.1M potassium phosphate buffer, Amano P lipoprotein lipase

With dmap; triethylamine; In dichloromethane; benzene;

DOI:10.1021/jo00045a042

upstream raw materials:

α,α',α''-trimethyl-1,3,5-benzenetrimethanol triacetate

α,α',α''-trimethyl-1,3,5-benzenetrimethanol

acetic anhydride

1,3,5-triacetylbenzene

Downstream raw materials:

(R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol