Technology Process of Benzoic acid, 4-hydroxy-3-(1-hydroxy-2,2-dimethylcyclopentyl)-, methyl ester
There total 3 articles about Benzoic acid, 4-hydroxy-3-(1-hydroxy-2,2-dimethylcyclopentyl)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-iodo-4-hydroxybenzoate;
With
methylmagnesium chloride; lithium isopropoxide;
In
tetrahydrofuran;
at -25 ℃;
for 1.41667h;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -25 ℃;
for 2.16667h;
2,2-dimethylcyclopentanone;
Further stages;
DOI:10.1021/jo200941r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium iodide / acetone / 18 h / Reflux
2.1: n-hexyllithium / tetrahydrofuran; hexane / 1.33 h / -20 - -5 °C
2.2: -5 - 20 °C
3.1: methylmagnesium chloride; lithium isopropoxide / tetrahydrofuran / 1.42 h / -25 °C
3.2: 2.17 h / -25 °C
With
methylmagnesium chloride; n-hexyllithium; lithium isopropoxide; sodium iodide;
In
tetrahydrofuran; hexane; acetone;
DOI:10.1021/jo200941r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-hexyllithium / tetrahydrofuran; hexane / 1.33 h / -20 - -5 °C
1.2: -5 - 20 °C
2.1: methylmagnesium chloride; lithium isopropoxide / tetrahydrofuran / 1.42 h / -25 °C
2.2: 2.17 h / -25 °C
With
methylmagnesium chloride; n-hexyllithium; lithium isopropoxide;
In
tetrahydrofuran; hexane;
DOI:10.1021/jo200941r
