(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

Base Information

Chemical Name:(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol
CAS No.:1612146-68-5
Molecular Formula:C₂₂H₃₁N₃O₂S
Molecular Weight:401.573
Hs Code.:

Synonyms:(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

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Chemical Property of (Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

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Technology Process of (Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

There total 5 articles about (Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1654741-61-3
C₁₂H₁₄O₃

: 104617-86-9
2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

: 1612146-68-5
(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

Guidance literature:: C₁₂H₁₄O₃; 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole; In dichloromethane; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃; for 36h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.08.021

Reference yield:

: (Z)-ethyl 5-(4-hydroxy-3-methoxyphenyl)pent-4-enoate

: 1612146-68-5
(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / -10 - 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 9 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

5.1: dichloromethane / 1 h / Inert atmosphere

5.2: 36 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.08.021

Reference yield:

: 1612146-44-7
(Z)-ethyl 5-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)pent-4-enoate

: 1612146-68-5
(Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / -10 - 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 9 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4.1: dichloromethane / 1 h / Inert atmosphere

4.2: 36 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2016.08.021