methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Base Information

Chemical Name:methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate
CAS No.:145300-58-9
Molecular Formula:C₃₄H₄₅NO₃Si
Molecular Weight:543.822
Hs Code.:

methyl 3-<<7-<1-<<dimethyl(1,1-dimethylethyl)silyl>oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Synonyms:methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Suppliers and Price of methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

There total 7 articles about methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 10602-06-9
methyl 3-ethynylbenzoate

: 145300-57-8
trifluoromethanesulfonic acid 7-<1-<oxy>nonyl>quinolin-2-yl ester

: 145300-58-9
methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Guidance literature:: With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine; for 6h;
DOI:10.1021/jm00074a012

Reference yield:

: 612-60-2
7-methylquinoline

: 145300-58-9
methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 46 percent / SeO₂ / 12 h / 150 - 155 °C

2: 1.) Mg / 1.) THF, reflux, 2.) THF, from -15 deg C to RT

3: 100 percent / 2,6-lutidine / CH₂Cl₂ / -10 - 20 °C

4: 87 percent / 80percent MCPBA / CH₂Cl₂ / 12 h / 0 °C

5: 99 percent / Et₃N, TFAA / tetrahydrofuran / 0.5 h / 0 °C

6: 66 percent / pyridine / 13 h / -20 - 20 °C

7: 96 percent / Et₃N, bis(triphenylphosphine)palladium(II) chloride, CuI / 6 h

With pyridine; 2,6-dimethylpyridine; copper(l) iodide; selenium(IV) oxide; bis(triphenylphosphine)palladium(II)-chloride; magnesium; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00074a012

Reference yield:

: 49573-30-0
quinoline-7-carbaldehyde

: 145300-58-9
methyl 3-<<7-<1-<oxy>nonyl>quinolin-2-yl>ethynyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg / 1.) THF, reflux, 2.) THF, from -15 deg C to RT

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / -10 - 20 °C

3: 87 percent / 80percent MCPBA / CH₂Cl₂ / 12 h / 0 °C

4: 99 percent / Et₃N, TFAA / tetrahydrofuran / 0.5 h / 0 °C

5: 66 percent / pyridine / 13 h / -20 - 20 °C

6: 96 percent / Et₃N, bis(triphenylphosphine)palladium(II) chloride, CuI / 6 h

With pyridine; 2,6-dimethylpyridine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; magnesium; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00074a012