(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

Base Information

Chemical Name:(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine
CAS No.:1286255-90-0
Molecular Formula:C₁₆H₁₂BrClFNO
Molecular Weight:368.633
Hs Code.:

Synonyms:(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

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Chemical Property of (5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

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Technology Process of (5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

There total 7 articles about (5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₁₆H₁₃BrFNO

: 1286255-90-0
(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

Guidance literature:: With 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; In 2,2,2-trifluoroethanol; at 24 ℃; enantioselective reaction;
DOI:10.1021/ol500861z

Reference yield: 99.0%

: 1286255-75-1
(E)-4-bromo-N-[3-(4-fluorophenyl)allyl]benzamide

: 1286255-90-0
(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

Guidance literature:: With 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; In trifluoroethanol; at -30 ℃; for 1h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201006910

Reference yield:

: C₁₆H₁₃BrFNO

: 1286255-90-0
(5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-fluorophenyl)-5,6-dihydro-4H-1,3-oxazine

: C₁₆H₁₂BrClFNO

Guidance literature:: With chloramine T trihydrate; 1,4-bis(9-O-dihydroquinidine)phthalazine; In 2,2,2-trifluoroethanol; at 24 ℃; Overall yield = 93 %; enantioselective reaction;
DOI:10.1021/ol500861z