Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate

Base Information

• Chemical Name: Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate
• CAS No.: 1026536-25-3
• Molecular Formula: C₁₆H₂₁N₃O₃
• Molecular Weight: 303.361

Synonyms:Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate

Chemical Property of Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate

Chemical Property:

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Technology Process of Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate

There total 2 articles about Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3-Dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylic acid ethyl ester (103409-28-5) + Cyclohexylmethyl bromide (2550-36-9) → Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate (1026536-25-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 0.5h;

DOI:10.1021/jo00111a014

Reference yield:

1,3-dihydro-imidazo[4,5-b]pyridin-2-one (16328-62-4) → Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate (1026536-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / acetonitrile / 1.5 h / Heating

2: 75 percent / K₂CO₃ / dimethylformamide / 0.5 h / 110 °C

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo00111a014

Reference yield: 80.0%

Ethyl 3-(cyclohexylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylate (1026536-25-3) → 3-(Cyclohexylmethyl)-1,3-dihydro-2H-imidazo<4,5-b>pyridine-2-one

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jo00111a014

upstream raw materials:

2,3-Dihydro-2-oxo-1H-imidazo<4,5-b>pyridine-1-carboxylic acid ethyl ester

Cyclohexylmethyl bromide

1,3-dihydro-imidazo[4,5-b]pyridin-2-one

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