N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide
CAS No.:1442468-31-6
Molecular Formula:C₂₈H₂₅NO₄S
Molecular Weight:471.577
Hs Code.:

Synonyms:N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Suppliers and Price of N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

There total 8 articles about N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: N-{3-[2-(di-tert-butylfluorosilyloxy)phenyl]-3-oxo-1,2-diphenylpropyl}-4-methylbenzenesulfonamide

: 1442468-31-6
N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Guidance literature:: N-{3-[2-(di-tert-butylfluorosilyloxy)phenyl]-3-oxo-1,2-diphenylpropyl}-4-methylbenzenesulfonamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

In tetrahydrofuran; aq. phosphate buffer; at 25 ℃; for 0.25h; pH=7; Inert atmosphere;

Inert atmosphere;
DOI:10.1002/adsc.201300244

Reference yield:

: 92151-73-0
2-phenylethynylphenol

: 1442468-31-6
N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 3 h / Inert atmosphere

3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 20 °C / Inert atmosphere

4.1: silver trifluoromethanesulfonate; gold(III) chloride / 1,2-dichloro-ethane / 1 h / 40 °C / Inert atmosphere

4.2: Inert atmosphere

4.3: Inert atmosphere

5.1: [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 3 h / 80 °C / Inert atmosphere

5.2: 6 h / -78 °C / Inert atmosphere

5.3: 1.25 h / -78 - 25 °C / pH 7 / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

6.2: 0.25 h / 25 °C / pH 7 / Inert atmosphere

6.3: Inert atmosphere

With dmap; gold(III) chloride; N-Bromosuccinimide; [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 5.1: |Mannich Aminomethylation / 5.2: |Mannich Aminomethylation / 5.3: |Mannich Aminomethylation;
DOI:10.1002/adsc.201300244

Reference yield:

: 1442467-96-0
di-tert-butyl[2-(phenylethynyl)phenoxy]silanol

: 1442468-31-6
N-[3-(2-hydroxyphenyl)-3-oxo-1,2-diphenylpropyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 3 h / 80 °C / Inert atmosphere

2.1: [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 3 h / 80 °C / Inert atmosphere

2.2: 6 h / -78 °C / Inert atmosphere

2.3: 1.25 h / -78 - 25 °C / pH 7 / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3.2: 0.25 h / 25 °C / pH 7 / Inert atmosphere

3.3: Inert atmosphere

With [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; 1,2-dichloro-ethane; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation / 2.3: |Mannich Aminomethylation;
DOI:10.1002/adsc.201300244