3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Base Information

Chemical Name:3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid
CAS No.:98527-26-5
Molecular Formula:C₈H₆BrClO₄
Molecular Weight:281.49
Hs Code.:
DSSTox Substance ID:DTXSID901238897

Synonyms:3-bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid;98527-26-5;SCHEMBL17410724;DTXSID901238897

Suppliers and Price of 3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:279.91380
Heavy Atom Count:14
Complexity:225

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1Cl)Br)O)C(=O)O

Technology Process of 3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

There total 3 articles about 3-Bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 84225-86-5
3-bromo-2-hydroxy-6-methoxysalicylic acid

: 98527-26-5
3-bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Guidance literature:: With thionyl chloride; In chloroform;
DOI:10.1021/jm00151a010

Reference yield: 57.4%

: 1830305-97-9
C₁₇H₂₃BrO₆

: 98527-26-5
3-bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Guidance literature:: With sulfuryl dichloride; In chloroform; at 20 - 40 ℃; for 12h;

Reference yield:

: 1466-76-8
2-6-dimethoxybenzoic acid

: 98527-26-5
3-bromo-5-chloro-2-hydroxy-6-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / chloroform / 30 h / 0 - 25 °C

2: dmap / tetrahydrofuran; dichloromethane / 7 h / 20 - 60 °C

3: sulfuryl dichloride / chloroform / 12 h / 20 - 40 °C

With dmap; sulfuryl dichloride; bromine; In tetrahydrofuran; dichloromethane; chloroform;