1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

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Chemical Name:1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine
CAS No.:690258-08-3
Molecular Formula:C₂₅H₂₇F₂N₅O₅
Molecular Weight:515.517
Hs Code.:

Synonyms:1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

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Chemical Property of 1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

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Technology Process of 1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

There total 5 articles about 1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690257-98-8
methyl (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-enyl]-L-phenylalaninate

: 690258-08-3
1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

1.2: 12 h / 20 °C

2.1: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol / 24 h / 20 °C

2.2: 10 h / 100 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C

With sodium hydroxide; potassium permanganate; sodium periodate; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; water; toluene; tert-butyl alcohol; 3.1: Suzuki Coupling;

Reference yield:

: 690258-04-9
(2S,3S,4E)-3-(4-bromophenyl)-1-(3,3-difluoropyrrolidin-1-yl)-1-oxohex-4-en-2-N-(tert-butoxycarbonyl)amine

: 690258-08-3
1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol / 24 h / 20 °C

1.2: 10 h / 100 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C

With potassium permanganate; sodium periodate; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; tert-butyl alcohol; 2.1: Suzuki Coupling;

Reference yield:

: 138888-98-9
N’-(5-bromopyridin-2-yl)-N,N-dimethylformimidamide

: 690258-08-3
1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; hydroxylamine-O-sulfonic acid / methanol / 0 - 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C

With pyridine; sodium carbonate; hydroxylamine-O-sulfonic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; water; toluene; 2: Suzuki Coupling;