Technology Process of 1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine
There total 5 articles about 1-[(2S,3S and 3R)-2-(tert-butoxycarbonylamino)-3-carboxy-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)1-oxopropanyl]-3,3-difluoropyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C
1.2: 12 h / 20 °C
2.1: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol / 24 h / 20 °C
2.2: 10 h / 100 °C
3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C
With
sodium hydroxide; potassium permanganate; sodium periodate; sodium carbonate; potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; ethanol; water; toluene; tert-butyl alcohol;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol / 24 h / 20 °C
1.2: 10 h / 100 °C
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C
With
potassium permanganate; sodium periodate; sodium carbonate; potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
ethanol; water; toluene; tert-butyl alcohol;
2.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine; hydroxylamine-O-sulfonic acid / methanol / 0 - 20 °C
2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 18 h / 100 °C
With
pyridine; sodium carbonate; hydroxylamine-O-sulfonic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; ethanol; water; toluene;
2: Suzuki Coupling;