Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate
CAS No.:188524-66-5
Molecular Formula:C13H13 N O2
Molecular Weight:215.25
Hs Code.:2933998090
DSSTox Substance ID:DTXSID90443083
Nikkaji Number:J849.142I
Wikidata:Q82260787
Mol file:188524-66-5.mol

Synonyms:188524-66-5;Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate;4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester;Methyl 4-(p-tolyl)-1H-pyrrole-3-carboxylate;1H-Pyrrole-3-carboxylic acid, 4-(4-methylphenyl)-, methyl ester;4-(4-METHYLPHENYL)-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER;DTXSID90443083;MFCD09746406;AKOS000369130;CS-0449373

Suppliers and Price of Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester 95%+
1g
$ 578.00

American Custom Chemicals Corporation
4-(4-METHYLPHENYL)-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER 95.00%
5MG
$ 504.79

Advanced Chemicals Intermediatesced Chemicals Intermediates
4-p-Tolyl-1H-pyrrole-3-carboxylicacidmethylester 95%+
5g
$ 978.75

Acints
4-p-Tolyl-1H-pyrrole-3-carboxylicacidmethylester 95%+
10g
$ 1732.75

Total 2 raw suppliers

Chemical Property of Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate

Chemical Property:

PSA：42.09000
LogP:2.77670
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:215.094628657
Heavy Atom Count:16
Complexity:246

Purity/Quality:

98% ^*data from raw suppliers

4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CNC=C2C(=O)OC

Technology Process of Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate

There total 2 articles about Methyl 4-(4-methylphenyl)-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 20754-20-5
3-p-tolyl-acrylic acid methyl ester

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 188524-66-5
4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester

Guidance literature:: With sodium hydride; In diethyl ether; dimethyl sulfoxide; for 1h; Heating;
DOI:10.1021/jo961981u

Reference yield:

: 7560-43-2,20754-20-5,50363-84-3
methyl 3-(4-methylphenyl)acrylate

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 188524-66-5
4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester

Guidance literature:: With sodium hydride; In diethyl ether; dimethyl sulfoxide; at 20 ℃; for 5h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.202016573

Reference yield:

: 188524-66-5
4-p-Tolyl-1H-pyrrole-3-carboxylic acid methyl ester

: 76304-54-6
3-(4-methylphenyl)pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / H₂O; methanol / 3 h / Heating

2: 0.25 g / 2-ethanolamine / 2 h / Heating

With potassium hydroxide; ethanolamine; In methanol; water;
DOI:10.1021/jo961981u