Bicyclo[3.2.0]heptan-2-amine, 1-methyl-, (1alpha,2beta,5alpha)- (9CI)

Base Information

• Chemical Name: Bicyclo[3.2.0]heptan-2-amine, 1-methyl-, (1alpha,2beta,5alpha)- (9CI)
• CAS No.: 188415-93-2
• Molecular Formula: C₈H₁₅N
• Molecular Weight: 125.214
• Mol file: 188415-93-2.mol

Synonyms:Bicyclo[3.2.0]heptan-2-amine,1-methyl-, (1a,2b,5a)- (9CI)

Chemical Property of Bicyclo[3.2.0]heptan-2-amine, 1-methyl-, (1alpha,2beta,5alpha)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[3.2.0]heptan-2-amine, 1-methyl-, (1alpha,2beta,5alpha)- (9CI)

There total 13 articles about Bicyclo[3.2.0]heptan-2-amine, 1-methyl-, (1alpha,2beta,5alpha)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-Dichloro-1-methylbicyclo[3.2.0]heptan-2-one → (1S,2S,5S)-1-Methyl-bicyclo[3.2.0]hept-2-ylamine (188415-93-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 2.) Na, t-BuOH / 2.) THF

2: H₂ / 10percent Pd/C / ethanol / 2 h / 1500.1 Torr

3: 5percent H₂SO₄ / 2 h

4: 90 percent / LiAlH₄ / diethyl ether

5: 82 percent / pyridine / 24 h / Ambient temperature

6: 80 percent / NaN₃ / dimethylsulfoxide / 24 h / 80 °C

7: LiAlH₄ / diethyl ether / 16 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sodium azide; sulfuric acid; hydrogen; sodium; tert-butyl alcohol; palladium on activated charcoal; In diethyl ether; ethanol; dimethyl sulfoxide;

DOI:10.1002/jlac.199719970211

Reference yield:

1-Methylspirobicyclo[3.2.0]hept-6-ene-2,2'-[1,3]dioxolane → (1S,2S,5S)-1-Methyl-bicyclo[3.2.0]hept-2-ylamine (188415-93-2)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / ethanol / 2 h / 1500.1 Torr

2: 5percent H₂SO₄ / 2 h

3: 90 percent / LiAlH₄ / diethyl ether

4: 82 percent / pyridine / 24 h / Ambient temperature

5: 80 percent / NaN₃ / dimethylsulfoxide / 24 h / 80 °C

6: LiAlH₄ / diethyl ether / 16 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sodium azide; sulfuric acid; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; dimethyl sulfoxide;

DOI:10.1002/jlac.199719970211

Reference yield:

6,7-Dichloro-1-methylbicyclo[3.2.0]heptan-2-one → (1S,2R,5S)-1-Methyl-bicyclo[3.2.0]hept-2-ylamine (188415-93-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) Na, t-BuOH / 2.) THF

2: H₂ / 10percent Pd/C / ethanol / 2 h / 1500.1 Torr

3: 5percent H₂SO₄ / 2 h

4: 49 percent / NH₂OH*HCl, aq. Na₂CO₃ / 4 h / Heating

5: Na, EtOH

With ethanol; sulfuric acid; hydroxylamine hydrochloride; hydrogen; sodium; sodium carbonate; tert-butyl alcohol; palladium on activated charcoal; In ethanol;

DOI:10.1002/jlac.199719970211

upstream raw materials:

1-methylbicyclo<3.2.0>heptan-2-one

1-Methylbicyclo<3.2.0>heptan-endo-2-ol