2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester
• CAS No.: 1187777-44-1
• Molecular Formula: C₁₉H₃₂O₃Si
• Molecular Weight: 336.547
• Mol file: 1187777-44-1.mol

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester

Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester

There total 1 articles about 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

t-butyldimethylsiyl triflate (69739-34-0) + 2-oxo-1-(buta-2-ynyl)cyclohexanecarboxylic acid ethyl ester (188616-36-6) → 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester (1187777-44-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol901722q

Reference yield: 90.0%

iodobenzene (591-50-4) + 2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester (1187777-44-1) → 2-(tert-butyldimethylsilanyloxy)-1-(3-phenyl-prop-2-ynyl)-cyclohex-2-enecarboxylic acid ethyl ester (1187777-45-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol901722q

Reference yield: 82.0%

2-(tert-butyl-dimethyl-silanyloxy)-1-but-2-ynylcyclohex-2-enecarboxylic acid ethyl ester (1187777-44-1) → 2-(tert-butyldimethylsilanyloxy)-1-(3-iodoprop-2-ynyl)-cyclohex-2-enecarboxylic acid ethyl ester

Guidance literature:

With N-iodo-succinimide; silver nitrate; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol901722q

upstream raw materials:

t-butyldimethylsiyl triflate

2-oxo-1-(buta-2-ynyl)cyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

2-(tert-butyldimethylsilanyloxy)-1-(3-phenyl-prop-2-ynyl)-cyclohex-2-enecarboxylic acid ethyl ester