Technology Process of (2R,3S,4R)-3-benzyloxycarbonylamino-4<(S)-1-hydroxy-ethyl>-2-methylcyclopentanone
There total 4 articles about (2R,3S,4R)-3-benzyloxycarbonylamino-4<(S)-1-hydroxy-ethyl>-2-methylcyclopentanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) diphenylphosphoryl azide, Et3N / 1.) r. t., 2 h, 2.) reflux, 1 h
2: 99 percent / NaIO4, OsO4 / 2-methyl-propan-2-ol; tetrahydrofuran / 6 h
3: 1.) L-selectride, 2.) 10percent NaOH, 30percent H2O2 / 1.) -78 deg C, THF, 20 min, 2.) 0 deg C
4: 70percent HClO4 / H2O; acetone / 3 h / Ambient temperature
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; perchloric acid; diphenylphosphoranyl azide; dihydrogen peroxide; L-Selectride; triethylamine;
In
tetrahydrofuran; water; acetone; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: PTSA / benzene / 4 h / Heating
2: 1.) diphenylphosphoryl azide, Et3N / 1.) r. t., 2 h, 2.) reflux, 1 h
3: 99 percent / NaIO4, OsO4 / 2-methyl-propan-2-ol; tetrahydrofuran / 6 h
4: 1.) L-selectride, 2.) 10percent NaOH, 30percent H2O2 / 1.) -78 deg C, THF, 20 min, 2.) 0 deg C
5: 70percent HClO4 / H2O; acetone / 3 h / Ambient temperature
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; perchloric acid; diphenylphosphoranyl azide; dihydrogen peroxide; L-Selectride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; water; acetone; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / NaIO4, OsO4 / 2-methyl-propan-2-ol; tetrahydrofuran / 6 h
2: 1.) L-selectride, 2.) 10percent NaOH, 30percent H2O2 / 1.) -78 deg C, THF, 20 min, 2.) 0 deg C
3: 70percent HClO4 / H2O; acetone / 3 h / Ambient temperature
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; perchloric acid; dihydrogen peroxide; L-Selectride;
In
tetrahydrofuran; water; acetone; tert-butyl alcohol;
![(6R,7S,8R)-8-Isopropenyl-6-methyl-1,4-dioxa-spiro[4.4]nonane-7-carboxylic acid](/Databaselist/images/loading.webp)
