2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Name:2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one
CAS No.:864155-79-3
Molecular Formula:C₃₉H₃₂N₄O₈
Molecular Weight:684.705
Hs Code.:

Synonyms:2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Property of 2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

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Technology Process of 2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

There total 1 articles about 2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 14215-97-5
1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

: 224946-82-1
2-amino-3-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

: 864155-79-3
2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: With tin(IV) chloride; In nitromethane; at 55 - 60 ℃; for 3h;
DOI:10.1081/NCN-200046784

Reference yield: 78.0%

: 864155-79-3
2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

: 864155-80-6
2-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one

Guidance literature:: With cyclohexene; palladium dihydroxide; In ethanol; at 120 - 125 ℃;
DOI:10.1081/NCN-200046784

Reference yield:

: 864155-79-3
2-amino-3-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

: 864155-89-5
2,4-dichloro-5-benzyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / cyclohexene / palladium(II) hydroxide on carbon / ethanol / 120 - 125 °C

2: 40 percent / phosphorus oxychloride; benzyltriethylammonium chloride; N,N-dimethylaniline / acetonitrile / 0.5 h / Heating

3: 71 percent / tert-butyl nitrite; antimony trichloride / 1,2-dichloro-ethane / 4 h / -10 °C

4: 85 percent / 1,8-diaza-bicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C

With tert.-butylnitrite; N-benzyl-N,N,N-triethylammonium chloride; antimony(III) chloride; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; cyclohexene; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1081/NCN-200046784