(22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃

Base Information

• Chemical Name: (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃
• CAS No.: 1417030-88-6
• Molecular Formula: C₃₃H₄₈O₄
• Molecular Weight: 508.742

Synonyms:(22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃

Chemical Property of (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃

There total 8 articles about (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(22E)-1-[(tert-butyldimethylsilyl)oxy]-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-19-norvitamin D3 tert-butyldimethylsilyl ether (1417030-87-5) → (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D3 (1417030-88-6)

Guidance literature:

With (1S)-10-camphorsulfonic acid; In ethanol; for 30h;

Reference yield:

2,4-nonanedione (6175-23-1) → (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D3 (1417030-88-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 20 h / Reflux

2.1: triethylamine; triethylsilyl trifluoromethyl sulfonate / dichloromethane / 0.5 h / 0 °C

3.1: toluene / 20 h / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h

4.2: 72 h

5.1: (1S)-10-camphorsulfonic acid / ethanol / 30 h

With (1S)-10-camphorsulfonic acid; triethylsilyl trifluoromethyl sulfonate; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; acetone; toluene;

Reference yield:

n-pentyl methyl ketone (110-43-0) → (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D3 (1417030-88-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / diethyl ether / 8 h / Reflux

2.1: potassium carbonate / acetone / 20 h / Reflux

3.1: triethylamine; triethylsilyl trifluoromethyl sulfonate / dichloromethane / 0.5 h / 0 °C

4.1: toluene / 20 h / Reflux

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h

5.2: 72 h

6.1: (1S)-10-camphorsulfonic acid / ethanol / 30 h

With (1S)-10-camphorsulfonic acid; triethylsilyl trifluoromethyl sulfonate; sodium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; toluene;

upstream raw materials:

2,4-nonanedione

n-pentyl methyl ketone

1-Acetyl-1-hexanoyl-cyclopropane

1-Bromoacetyl-1-hexanoyl-cyclopropane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1417030-88-6 (22E)-2-methylene-24-oxo-25-hexanoyl-26,27-cyclo-22-dehydro-hydroxy-19-norvitamin D₃

Send

Send

Metric Ton KG G Pound L ML

Send

Send