3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI)

Base Information

Chemical Name:3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI)
CAS No.:188242-02-6
Molecular Formula:C₇H₁₀N₂O
Molecular Weight:138.169
Hs Code.:
Mol file:188242-02-6.mol

Synonyms:3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI)

Chemical Property:

Boiling Point:277.6±40.0 °C(Predicted)
PKA:13.57±0.40(Predicted)
PSA：0.00000
Density:1.17±0.1 g/cm3(Predicted)
LogP:0.00000

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI)

There total 3 articles about 3-Pyridinecarbonitrile,1,4,5,6-tetrahydro-5-hydroxy-1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 188241-98-7
(4aR,8aS,9aR,10aS)-1,5-Dimethyl-1,4,4a,5,8,8a,9a,10a-octahydro-9,10-dioxa-1,5-diaza-anthracene-3,7-dicarbonitrile

: 188242-02-6
3-hydroxy-1-methyl-1,2,3,4-tetrahydropyridine-5-carbonitrile

Guidance literature:: With triethylsilane; titanium tetrachloride; In tetrahydrofuran; at -60 ℃; for 0.0833333h;
DOI:10.1039/a606919c

Reference yield: 95.0%

: 1,5-dimethyl-1,4,4a,5,8,8a,9a,10a-octahydro-9,10-dioxa-1,5-diaza-anthracene-3,7-dicarbonitrile

: 188242-02-6
3-hydroxy-1-methyl-1,2,3,4-tetrahydropyridine-5-carbonitrile

Guidance literature:: With triethylsilane; titanium tetrachloride; In dichloromethane; at -60 ℃; for 0.0833333h;
DOI:10.1021/jo980688m

Reference yield:

: 19424-15-8
1-methyl-1,4-dihydropyridine-3-carbonitrile

: 188242-02-6
3-hydroxy-1-methyl-1,2,3,4-tetrahydropyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / DMD / acetone / 0 °C

2: 95 percent / TiCl₄, Et₃SiH / CH₂Cl₂ / 0.08 h / -60 °C

With triethylsilane; DMd; titanium tetrachloride; In dichloromethane; acetone;
DOI:10.1021/jo980688m