<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

Base Information

Chemical Name:<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol
CAS No.:146434-01-7
Molecular Formula:C₃₀H₄₂O₂Si
Molecular Weight:462.748
Hs Code.:

Synonyms:<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

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Chemical Property of <1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

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Technology Process of <1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

There total 7 articles about <1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 146434-00-6
<1R-(1α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-1,2,3,6,7,7a-hexahydro-7a-methyl-5H-inden-5-one

: 146434-01-7
<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In ethanol; at -78 ℃; for 0.333333h;
DOI:10.1021/jo00058a032

Reference yield:

: 131336-04-4
(2R,3R)-3-<(1R)-2-(methoxycarbonyl)-1-methylethyl>-2-methylcyclopentanone

: 146434-01-7
<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 76 percent / NaBrO₂ / H₂O; acetic acid / 7 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

4: 60 percent / KOH / methanol; H₂O / 1) room temperature, 14 h, 2) reflux, 4 h

5: 85 percent / NaBH₄, CeCl₃*7H₂O / ethanol / 0.33 h / -78 °C

With 1H-imidazole; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; sodium bromite; In methanol; diethyl ether; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a032

Reference yield:

: (2R,3R)-3-((R)-3-Hydroxy-1-methyl-propyl)-2-methyl-cyclopentanol

: 146434-01-7
<1R-(1α,5α,7aα)>-1-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2,3,5,6,7,7a-hexahydro-7a-methyl-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / NaBrO₂ / H₂O; acetic acid / 7 h / Ambient temperature

2: 98 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

3: 60 percent / KOH / methanol; H₂O / 1) room temperature, 14 h, 2) reflux, 4 h

4: 85 percent / NaBH₄, CeCl₃*7H₂O / ethanol / 0.33 h / -78 °C

With 1H-imidazole; potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; sodium bromite; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a032