Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-

Base Information

Chemical Name:Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-
CAS No.:188176-10-5
Molecular Formula:C₂₅H₃₅NO₇
Molecular Weight:461.555
Hs Code.:

Synonyms:Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-

Suppliers and Price of Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-

Chemical Property:

PSA：122.49000
LogP:3.12400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy-

There total 7 articles about Propanoic acid, 2-methyl-, (3beta,7beta,19E)-19-[(carboxymethoxy)imino]-3-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 188176-09-2
Benzoic acid (3S,7R,8R,9S,10S,13S,14S)-7-isobutyryloxy-10-(methoxycarbonylmethoxyimino-methyl)-13-methyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 188176-11-6,213695-71-7
[1-((3S,7R,8R,9S,10S,13S,14S)-3,7-Dihydroxy-13-methyl-17-oxo-1,2,3,4,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-10-yl)-meth-(E)-ylideneaminooxy]-acetic acid

: 188176-10-5
Isobutyric acid (3S,7R,8R,9S,10S,13S,14S)-10-(carboxymethoxyimino-methyl)-3-hydroxy-13-methyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl ester

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 24h;
DOI:10.1135/cccc19970109

Reference yield:

: 188175-95-3
Benzoic acid (3S,8R,9S,10S,13S,14S,17S)-17-acetoxy-10-(carboxymethoxyimino-methyl)-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 188176-10-5
Isobutyric acid (3S,7R,8R,9S,10S,13S,14S)-10-(carboxymethoxyimino-methyl)-3-hydroxy-13-methyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether; methanol / 0.08 h / 0 °C

2: 51 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 3 h / -20 °C

3: 83 percent / CeCl₃*5H₂O, NaBH₄ / tetrahydrofuran; methanol / 0.12 h

4: 94 percent / pyridine / 3 h / 0 °C

5: 78 percent / conc. HCl / CHCl₃; methanol / 21 h / Ambient temperature

6: 67 percent / Jones reagent / acetone / 0.08 h / Ambient temperature

7: 40 percent / aq. NaOH / tetrahydrofuran; methanol / 24 h / 60 °C

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; jones reagent; cerium(III) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; acetone;
DOI:10.1135/cccc19970109

Reference yield:

: 188175-96-4
Benzoic acid (3S,8R,9S,10S,13S,14S,17S)-17-acetoxy-10-(methoxycarbonylmethoxyimino-methyl)-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 188176-10-5
Isobutyric acid (3S,7R,8R,9S,10S,13S,14S)-10-(carboxymethoxyimino-methyl)-3-hydroxy-13-methyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 51 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 3 h / -20 °C

2: 83 percent / CeCl₃*5H₂O, NaBH₄ / tetrahydrofuran; methanol / 0.12 h

3: 94 percent / pyridine / 3 h / 0 °C

4: 78 percent / conc. HCl / CHCl₃; methanol / 21 h / Ambient temperature

5: 67 percent / Jones reagent / acetone / 0.08 h / Ambient temperature

6: 40 percent / aq. NaOH / tetrahydrofuran; methanol / 24 h / 60 °C

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; jones reagent; cerium(III) chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetone;
DOI:10.1135/cccc19970109