1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Base Information

Chemical Name:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride
CAS No.:1218762-60-7
Molecular Formula:C₂₇H₂₉F₇N₄O₂*ClH
Molecular Weight:611.003
Hs Code.:

Synonyms:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Suppliers and Price of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

There total 3 articles about 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1218762-59-4
tert-butyl 4-{[(3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidin-1-yl]carbonyl}piperidine-1-carboxylate

: 1218762-60-7
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 45 ℃; for 3h;

Reference yield:

: 1218761-04-6
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

: 1218762-60-7
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 6 h / 10 - 35 °C

2: hydrogenchloride / isopropyl alcohol / 3 h / 45 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In isopropyl alcohol; acetonitrile;

Reference yield:

: 1218761-03-5
tert-butyl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

: 1218762-60-7
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-(piperidin-4-ylcarbonyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / isopropyl alcohol / 2.5 h / 10 - 45 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 6 h / 10 - 35 °C

3: hydrogenchloride / isopropyl alcohol / 3 h / 45 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In isopropyl alcohol; acetonitrile;