2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

Base Information

Chemical Name:2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole
CAS No.:1542265-50-8
Molecular Formula:C₂₀H₂₃IN₄
Molecular Weight:446.334
Hs Code.:

Synonyms:2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

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Technology Process of 2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

There total 6 articles about 2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 900506-24-3
4-((4-methylpiperazin-1-yl)methyl)benzene-1,2-diamine

: 82998-57-0
3-iodo-4-toluic acid

: 1542265-50-8
2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 1542265-50-8
2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride; triethylamine / dichloromethane / 6 h / 5 °C / Heating; Reflux

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / dichloromethane; tetrahydrofuran; methanol / 5 h / -5 - 20 °C

3: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 12 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 896466-69-6
(3,4-dinitrophenyl)-(4-methylpiperazin-1-yl)-methanone

: 1542265-50-8
2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / dichloromethane; tetrahydrofuran; methanol / 5 h / -5 - 20 °C

2: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 12 h

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;