(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

Base Information

Chemical Name:(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate
CAS No.:1363365-20-1
Molecular Formula:C₁₆H₁₇N₃O₅
Molecular Weight:331.328
Hs Code.:

Synonyms:(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

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Chemical Property of (1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

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Technology Process of (1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

There total 3 articles about (1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 15177-67-0
trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

: 192332-48-2
(Z)-4-nitrobenzamidoxime

: 1363365-20-1
(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

Guidance literature:: trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

(Z)-4-nitrobenzamidoxime; In dichloromethane; at 20 ℃; for 8h;

In toluene; for 16h; Reflux;

Reference yield:

: 619-72-7
4-nitrobenzonitrile

: 1363365-20-1
(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / Reflux

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

2.2: 8 h / 20 °C

2.3: 16 h / Reflux

With potassium carbonate; 1,1'-carbonyldiimidazole; In dichloromethane;

Reference yield:

: 3399-22-2
dimethyl 1,4-cyclohexanedicarboxylate

: 1363365-20-1
(1r,4r)-methyl 4-(3-(4-nitrophenyl)-1,2,4-oxadiazol-5-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 5 h / Reflux

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

2.2: 8 h / 20 °C

2.3: 16 h / Reflux

With 1,1'-carbonyldiimidazole; potassium hydroxide; In methanol; dichloromethane;